UBE3D

Across TCGA pan-cancer cohorts, UBE3D Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBE3D data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UBE3D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated UBE3D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and MESO are the cancer types where UBE3D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.438	.018	22	view →
LUSC	OS	Median	II,III,IV	0.147	0.732	.002	18	view →
MESO	DFS	Median	All	0.099	0.392	.030	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LUAD	DFS	Median	All	0.389	0.770	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBE3D–UCEC (DFS)

Open the UCEC breakdown →