UBE3C

Across TCGA pan-cancer cohorts, UBE3C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBE3C data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher UBE3C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE3C expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KICH, UCEC, and SARC are the cancer types where UBE3C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.081	0.904	<.001	30	view →
UCEC	DFS	Median	All	0.765	0.630	.008	20	view →
SARC	DFS	Median	All	0.006	0.591	<.001	3	view →
LUAD	DFS	Median	II,III,IV	0.258	0.683	.048	3	view →
SKCM	OS	Median	All	1.000	0.867	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBE3C–KICH (DFS)

Open the KICH breakdown →