UBE3C

Across TCGA pan-cancer cohorts, UBE3C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBE3C data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher UBE3C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBE3C expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

GBM, LUAD, and PDAC are the cancer types where UBE3C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.181	0.347	<.001	40	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.614	.001	22	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Median	All	0.936	1.000	.023	2	view →
CCRCC	OS	Median	III,IV	0.485	1.000	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBE3C–GBM (DFS)

Open the GBM breakdown →