UBE3C

Across TCGA patient cohorts, UBE3C mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE3C-associated genes across cancer lineages are p53, Caspase-7-cleavedD198, and Notch1. Each is linked with UBE3C in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE3C-to-partner and partner-to-UBE3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by UBE3C-low versus UBE3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3C→partner) and Y-score (partner→UBE3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.273	-1.700	.018	.040	3	3
COAD	Caspase-7-cleavedD198 →	+1.155	+3.178	.002	.010	3	2
UCEC	Notch1 →	+0.150	+1.375	<.001	.020	3	2
UCEC	p27_pT198 →	+0.076	+1.584	.017	.002	3	2
UCEC	p62 Lck ligand →	+0.355	+1.807	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.146	-1.378	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p53 by UBE3C expression — UCEC

Explore this box plot interactively →