UBE3C

Across TCGA cell cohorts, UBE3C mutation is significantly associated with the RNA expression of many other genes, with 335 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE3C-associated genes across cancer lineages are SCGB2A2, CRP, and SCGB3A1. Each is linked with UBE3C in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE3C-to-partner and partner-to-UBE3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB2A2 grouped by UBE3C-low versus UBE3C-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3C→partner) and Y-score (partner→UBE3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGB2A2 →	+1.392	+3.781	<.001	.004	3	1
CNS	CRP →	+0.175	+3.584	<.001	.003	3	1
CNS	SCGB3A1 →	+0.107	+4.409	.004	<.001	3	1
BLOOD_Leukemia	SMIM43 →	+0.543	+3.345	<.001	.009	3	1
BLOOD_Leukemia	CTRB2 →	+0.119	+3.177	<.001	.004	3	1
BLOOD_Leukemia	TCEAL2 →	+0.522	+4.354	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 335 associations by consensus.

SCGB2A2 by UBE3C expression — CNS

Explore this box plot interactively →