UBE3C

Across TCGA cell cohorts, UBE3C mutation is significantly associated with the mutation status of many other genes, with 6,893 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE3C-associated genes across cancer lineages are LRPPRC, GRM3, and AFF2. Each is linked with UBE3C in more than 4 cancer types. Because this analysis shows association rather than direction, both UBE3C-to-partner and partner-to-UBE3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRPPRC grouped by UBE3C-low versus UBE3C-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE3C→partner) and Y-score (partner→UBE3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRPPRC →	+5.000	+4.044	.008	.008	1	5
CNS	GRM3 →	+3.263	+3.554	.005	.005	1	5
BLOOD_Lymphoma	AFF2 →	+3.362	+4.754	.002	.002	1	5
BLOOD_Lymphoma	SCRIB →	+3.847	+5.108	.001	.001	1	5
BLOOD_Lymphoma	CAMSAP3 →	+3.584	+4.922	.001	.001	1	5
STOMACH	PLXNA1 →	+3.357	+4.285	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,893 associations by consensus.

LRPPRC by UBE3C expression — CNS

Explore this box plot interactively →