UBE2Z

Across TCGA pan-cancer cohorts, UBE2Z RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UBE2Z’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2Z RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2Z is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where UBE2Z tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2Z RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.103	<.001	12	view →
KIRP	All	III,IV	+0.970	<.001	11	view →
KIRC	All	IV	+0.560	<.001	11	view →
LUAD	Male	III,IV	+0.844	<.001	10	view →
LIHC	Female	II,III,IV	+1.291	<.001	9	view →
STAD	Male	II,III,IV	+0.845	<.001	8	view →
LUSC	Male	All	+0.680	<.001	8	view →
KICH	Female	II,III,IV	−1.204	<.001	7	view →
BRCA	All	III,IV	+0.830	<.001	6	view →
BLCA	Female	All	+0.575	.012	6	view →
CHOL	Female	All	+2.833	<.001	5	view →
COAD	Male	II,III,IV	+0.278	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

UBE2Z–HNSC

Open the HNSC breakdown →