UBE2R2

Across TCGA pan-cancer cohorts, UBE2R2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBE2R2 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBE2R2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBE2R2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where UBE2R2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.955	0.728	.005	22	view →
GBM	DFS	Quartile	All	0.237	0.429	.002	13	view →
CCRCC	OS	Median	II,III,IV	0.860	0.589	.006	12	view →
LSCC	DFS	Quartile	All	0.546	0.787	.019	5	view →
PDAC	DFS	Tertile	II,III,IV	0.879	0.719	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBE2R2–HNSC (OS)

Open the HNSC breakdown →