UBE2R2

Across TCGA patient cohorts, UBE2R2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2R2-associated genes across cancer lineages are eIF4E, Ku80, and MAPK_pT202_Y204. Each is linked with UBE2R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2R2-to-partner and partner-to-UBE2R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBE2R2-low versus UBE2R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2R2→partner) and Y-score (partner→UBE2R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+3.000	.047	.036	3	1
UCEC	Ku80 →	+0.291	+3.598	.010	.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.466	-3.000	.040	.036	3	1
UCEC	NF2 →	+0.300	+2.999	.004	.035	3	1
UCEC	p62 Lck ligand →	+0.418	+3.009	.007	.019	3	1
UCEC	14-3-3_beta →	-0.113	-2.446	.020	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by UBE2R2 expression — UCEC

Explore this box plot interactively →