Across TCGA pan-cancer cohorts, UBE2Q2P12 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of UBE2Q2P12’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where UBE2Q2P12 RNA is repressed in tumor relative to normal tissue. In most cancer types UBE2Q2P12 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
LUSC and HNSC are the cancer types where UBE2Q2P12 tumor–normal differential expression is most reproducible.