UBE2Q1

Across TCGA cell cohorts, UBE2Q1 mutation is significantly associated with the mutation status of many other genes, with 1,632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE2Q1-associated genes across cancer lineages are TBC1D17, CCDC85A, and SELENON. Each is linked with UBE2Q1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE2Q1-to-partner and partner-to-UBE2Q1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D17 grouped by UBE2Q1-low versus UBE2Q1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2Q1→partner) and Y-score (partner→UBE2Q1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D17 →	+3.672	+4.799	.002	.002	1	3
SKIN	CCDC85A →	+4.824	+5.392	.004	.004	1	3
LARGE_INTESTINE	SELENON →	+5.087	+4.523	.006	.006	1	2
SKIN	SHROOM1 →	+5.824	+5.824	.002	.002	1	2
SKIN	ZNF791 →	+5.824	+5.824	.002	.002	1	2
SKIN	ZCCHC3 →	+4.824	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,632 associations by consensus.

TBC1D17 by UBE2Q1 expression — LARGE_INTESTINE

Explore this box plot interactively →