UBE2NL

Across TCGA patient cohorts, UBE2NL mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2NL-associated genes across cancer lineages are SMYD4, HAUS1, and H2AZ1. Each is linked with UBE2NL in more than 2 cancer types. Because this analysis shows association rather than direction, both UBE2NL-to-partner and partner-to-UBE2NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMYD4 grouped by UBE2NL-low versus UBE2NL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2NL→partner) and Y-score (partner→UBE2NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMYD4 →	+0.402	+3.386	.002	.004	3	3
COAD	HAUS1 →	+0.681	+2.754	<.001	.003	3	3
COAD	H2AZ1 →	+0.483	+2.713	.001	.003	3	3
COAD	PTTG1 →	+0.624	+2.615	<.001	.005	3	3
LUSC	DMRTA1 →	-0.722	-3.459	.005	.005	3	3
READ	OR2T1 →	+0.081	+5.096	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

SMYD4 by UBE2NL expression — UCEC

Explore this box plot interactively →