UBE2NL

Across TCGA patient cohorts, UBE2NL mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2NL-associated genes across cancer lineages are GAPDH, STAT3_pY705, and c-Jun_pS73. Each is linked with UBE2NL in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2NL-to-partner and partner-to-UBE2NL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UBE2NL-low versus UBE2NL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2NL→partner) and Y-score (partner→UBE2NL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.709	+2.182	.001	.033	3	2
UCEC	STAT3_pY705 →	-0.491	-2.584	<.001	.011	3	2
UCEC	c-Jun_pS73 →	-0.170	-2.990	.021	.036	3	2
COAD	MEK1 →	+0.200	+3.017	.021	.017	3	2
COAD	ASNS →	+0.500	+2.467	.003	.011	3	2
COAD	ATM →	-0.650	-3.459	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GAPDH by UBE2NL expression — COAD

Explore this box plot interactively →