UBE2L6

Across TCGA patient cohorts, UBE2L6 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2L6-associated genes across cancer lineages are MIG-6, Notch1, and PCNA. Each is linked with UBE2L6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2L6-to-partner and partner-to-UBE2L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by UBE2L6-low versus UBE2L6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2L6→partner) and Y-score (partner→UBE2L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.107	+2.183	.039	.035	3	1
UCEC	Notch1 →	+0.233	+2.820	.001	.035	3	1
UCEC	PCNA →	+0.258	+3.000	.022	.036	3	1
UCEC	PDCD4 →	-0.607	-3.321	.013	.010	3	1
UCEC	STAT3_pY705 →	-0.502	-3.169	<.001	.018	3	1
UCEC	Cyclin-B1 →	+0.820	+3.000	.005	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MIG-6 by UBE2L6 expression — UCEC

Explore this box plot interactively →