UBE2L6

Across TCGA cell cohorts, UBE2L6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,384 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBE2L6-associated GO terms across cancer lineages are ISG15-protein conjugation, Defense response to virus, and Antigen processing and presentation of endogenous antigen. Each is linked with UBE2L6 in more than 16 cancer types. Because this analysis shows association rather than direction, both UBE2L6-to-partner and partner-to-UBE2L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ISG15-protein conjugation grouped by UBE2L6-low versus UBE2L6-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2L6→partner) and Y-score (partner→UBE2L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ISG15-protein conjugation →	+0.290	+2.219	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.091	+2.015	<.001	<.001	3	17
BREAST	Antigen processing and presentation of endogenous antigen →	+0.223	+2.369	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	CD8-positive, alpha-beta T cell homeostasis →	+0.218	+2.897	<.001	<.001	3	15
URINARY_TRACT	Negative regulation of regulatory T cell differentiation →	+0.207	+1.864	<.001	<.001	3	15
PANCREAS	CD8-positive, alpha-beta T cell differentiation →	+0.130	+1.742	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,384 associations by consensus.

ISG15-protein conjugation by UBE2L6 expression — STOMACH

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