Across TCGA patient cohorts, UBE2L3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2L3-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with UBE2L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2L3-to-partner and partner-to-UBE2L3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2L3→partner) and Y-score (partner→UBE2L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.100	-3.143	.015	.018	3	1
UCEC	eEF2 →	+0.388	+1.807	.008	.027	3	1
UCEC	EGFR_pY1068 →	-0.430	-3.906	<.001	<.001	3	1
UCEC	eIF4E →	+0.211	+2.584	.015	.010	3	1
UCEC	Heregulin →	-0.182	-3.308	<.001	.009	3	1
UCEC	INPP4B →	-0.394	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

UBE2L3 survival (RNA) · tumor vs normal (RNA) · all UBE2L3 data types