UBE2K

Across TCGA pan-cancer cohorts, UBE2K mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UBE2K’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where UBE2K mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2K is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

LUAD, COAD, and LSCC are the cancer types where UBE2K tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2K mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.371	<.001	9	view →
COAD	Male	II,III,IV	−0.203	<.001	9	view →
LSCC	Male	All	+0.264	<.001	8	view →
CCRCC	Male	All	−0.101	<.001	6	view →
HNSC	All	III,IV	+0.120	.003	4	view →
OV	All	All	+0.420	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UBE2K–LUAD

Open the LUAD breakdown →