Across TCGA pan-cancer cohorts, UBE2F RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of UBE2F’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBE2F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBE2F is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
HNSC, KICH, and LIHC are the cancer types where UBE2F tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2F RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.