UBE2E3

Across TCGA patient cohorts, UBE2E3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2E3-associated genes across cancer lineages are EGFR_pY1173, ER-alpha, and INPP4B. Each is linked with UBE2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2E3-to-partner and partner-to-UBE2E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by UBE2E3-low versus UBE2E3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2E3→partner) and Y-score (partner→UBE2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.069	+1.727	.042	.026	3	1
UCEC	ER-alpha →	-0.735	-1.700	.035	.044	3	1
UCEC	INPP4B →	-0.282	-1.687	.040	.044	3	1
UCEC	JNK2 →	+0.248	+1.700	.003	.044	3	1
UCEC	MSH2 →	-0.326	-1.990	<.001	.030	3	1
UCEC	p27_pT198 →	+0.096	+2.222	.035	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1173 by UBE2E3 expression — UCEC

Explore this box plot interactively →