UBE2E3

Across TCGA cell cohorts, UBE2E3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible UBE2E3-associated genes across cancer lineages are GNG8, WFDC6, and C1orf232. Each is linked with UBE2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2E3-to-partner and partner-to-UBE2E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNG8 grouped by UBE2E3-low versus UBE2E3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2E3→partner) and Y-score (partner→UBE2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNG8 →	+0.479	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.047	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GNG8 by UBE2E3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →