UBE2E2

Across TCGA pan-cancer cohorts, UBE2E2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of UBE2E2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where UBE2E2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types UBE2E2 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and LUAD are the cancer types where UBE2E2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBE2E2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.382	<.001	11	view →
PDAC	Male	III,IV	−0.506	.026	1	view →
LUAD	Female	III,IV	+0.463	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

UBE2E2–CCRCC

Open the CCRCC breakdown →