UBE2E2

Across TCGA patient cohorts, UBE2E2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2E2-associated genes across cancer lineages are GATA6, JNK2, and STAT3_pY705. Each is linked with UBE2E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2E2-to-partner and partner-to-UBE2E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by UBE2E2-low versus UBE2E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2E2→partner) and Y-score (partner→UBE2E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.178	-2.314	.022	.035	3	1
UCEC	JNK2 →	+0.300	+3.026	.001	.018	3	1
UCEC	STAT3_pY705 →	-0.432	-2.459	<.001	.020	3	1
UCEC	Tuberin →	+0.399	+3.009	.002	.019	3	1
UCEC	ASNS →	+0.478	+3.169	.006	.019	3	1
UCEC	14-3-3_zeta →	-0.212	-3.150	.033	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

GATA6 by UBE2E2 expression — UCEC

Explore this box plot interactively →