UBE2D4

Across TCGA cell cohorts, UBE2D4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,802 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible UBE2D4-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Protein K63-linked ubiquitination, and Positive regulation of early endosome to late endosome transport. Each is linked with UBE2D4 in more than 9 cancer types. Because this analysis shows association rather than direction, both UBE2D4-to-partner and partner-to-UBE2D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by UBE2D4-low versus UBE2D4-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2D4→partner) and Y-score (partner→UBE2D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.130	+0.733	.009	.008	1	10
URINARY_TRACT	Protein K63-linked ubiquitination →	+0.051	+0.779	.001	<.001	2	8
URINARY_TRACT	Positive regulation of early endosome to late endosome transport →	+0.118	+0.794	<.001	<.001	3	7
LARGE_INTESTINE	Brush border assembly →	-0.635	-0.422	.007	.002	3	7
SOFT_TISSUE	Positive regulation of triglyceride catabolic process →	+0.144	+0.808	.002	.002	3	6
LUNG_NSCLC_LUSC	Malate metabolic process →	-0.204	-1.061	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,802 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by UBE2D4 expression — LIVER

Explore this box plot interactively →