UBE2D2

Across TCGA patient cohorts, UBE2D2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2D2-associated genes across cancer lineages are c-Met_pY1235, JNK_pT183_Y185, and MEK1. Each is linked with UBE2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2D2-to-partner and partner-to-UBE2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by UBE2D2-low versus UBE2D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2D2→partner) and Y-score (partner→UBE2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.074	+3.009	.039	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.160	-2.321	.049	.034	3	1
UCEC	MEK1 →	+0.420	+2.459	.017	.020	3	1
UCEC	mTOR_pS2448 →	-0.180	-2.986	.012	.035	3	1
UCEC	NDRG1_pT346 →	-0.523	-2.999	.027	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.539	-2.999	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

c-Met_pY1235 by UBE2D2 expression — UCEC

Explore this box plot interactively →