UBE2D2

Across TCGA cell cohorts, UBE2D2 mutation is significantly associated with the mutation status of many other genes, with 787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBE2D2-associated genes across cancer lineages are CELF2, KARS1, and RHOA. Each is linked with UBE2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2D2-to-partner and partner-to-UBE2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELF2 grouped by UBE2D2-low versus UBE2D2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2D2→partner) and Y-score (partner→UBE2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CELF2 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	KARS1 →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	RHOA →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	PITX1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	FGD1 →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	PSMD11 →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

CELF2 by UBE2D2 expression — LARGE_INTESTINE

Explore this box plot interactively →