UBE2B

Across TCGA pan-cancer cohorts, UBE2B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated UBE2B data layer compared with 28 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UBE2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UBE2B expression acts as an unfavorable survival marker.

UVM and COAD are the cancer types where UBE2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.248	0.769	.007	12	view →
COAD	OS	Median	II,III,IV	0.111	0.853	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

UBE2B–UVM (OS)

Open the UVM breakdown →