UBE2B

Across TCGA patient cohorts, UBE2B mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2B-associated genes across cancer lineages are NDUFA5P7, EIF4E, and CATSPER3. Each is linked with UBE2B in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2B-to-partner and partner-to-UBE2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P7 grouped by UBE2B-low versus UBE2B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2B→partner) and Y-score (partner→UBE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NDUFA5P7 →	+0.203	+7.640	<.001	.009	3	1
UCEC	EIF4E →	+0.446	+3.191	.007	.009	3	1
UCEC	CATSPER3 →	+0.371	+2.807	.003	.003	3	1
UCEC	RAD17 →	+0.452	+2.642	.008	.005	3	1
UCEC	WHAMM →	+0.592	+3.764	<.001	<.001	3	1
UCEC	CXCL13 →	+1.743	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

NDUFA5P7 by UBE2B expression — BLCA

Explore this box plot interactively →