UBE2A

Across TCGA patient cohorts, UBE2A mutation is significantly associated with the RNA expression of many other genes, with 2,591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2A-associated genes across cancer lineages are RNU1-17P, RNA5SP412, and RNU6-440P. Each is linked with UBE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2A-to-partner and partner-to-UBE2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by UBE2A-low versus UBE2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2A→partner) and Y-score (partner→UBE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU1-17P →	+0.207	+4.588	<.001	.008	3	2
UCEC	RNA5SP412 →	+0.446	+2.049	<.001	.001	3	2
UCEC	RNU6-440P →	+0.096	+3.111	.001	.004	3	2
UCEC	EIF3JP1 →	+0.127	+1.935	.002	.002	3	2
UCEC	RNA5SP413 →	+0.939	+1.599	<.001	.006	3	2
UCEC	RNA5SP422 →	+0.527	+1.753	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,591 associations by consensus.

RNU1-17P by UBE2A expression — BLCA

Explore this box plot interactively →