UBE2A

Across TCGA patient cohorts, UBE2A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBE2A-associated genes across cancer lineages are eEF2, eIF4G, and ERK2. Each is linked with UBE2A in more than 1 cancer types. Because this analysis shows association rather than direction, both UBE2A-to-partner and partner-to-UBE2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by UBE2A-low versus UBE2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBE2A→partner) and Y-score (partner→UBE2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.445	+2.087	.001	.005	3	1
UCEC	eIF4G →	+0.304	+1.678	.010	.023	3	1
UCEC	ERK2 →	+0.280	+2.807	<.001	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.133	-2.405	.005	.003	3	1
UCEC	GAPDH →	+0.729	+3.807	<.001	<.001	3	1
UCEC	GATA6 →	-0.159	-2.307	.008	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by UBE2A expression — UCEC

Explore this box plot interactively →