UBC

Across TCGA patient cohorts, UBC mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBC-associated genes across cancer lineages are ASNS, eEF2, and ERK2. Each is linked with UBC in more than 1 cancer types. Because this analysis shows association rather than direction, both UBC-to-partner and partner-to-UBC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UBC-low versus UBC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBC→partner) and Y-score (partner→UBC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.628	+3.321	<.001	.010	3	2
UCEC	eEF2 →	+0.460	+2.999	.005	.035	3	1
UCEC	ERK2 →	+0.255	+2.999	.004	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.121	-2.312	.037	.034	3	1
UCEC	INPP4B →	-0.376	-2.459	.012	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by UBC expression — UCEC

Explore this box plot interactively →