UBC

Across TCGA cell cohorts, UBC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,862 significant associations in total. CNS shows the largest number of these associations.

The most reproducible UBC-associated GO terms across cancer lineages are Intracellular receptor signaling pathway, Negative regulation of autophagy, and Regulation of cytokine-mediated signaling pathway. Each is linked with UBC in more than 12 cancer types. Because this analysis shows association rather than direction, both UBC-to-partner and partner-to-UBC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular receptor signaling pathway grouped by UBC-low versus UBC-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBC→partner) and Y-score (partner→UBC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.064	+0.825	<.001	<.001	3	13
URINARY_TRACT	Negative regulation of autophagy →	+0.066	+0.888	<.001	<.001	3	12
SOFT_TISSUE	Regulation of cytokine-mediated signaling pathway →	+0.050	+0.688	.001	<.001	3	12
PANCREAS	Positive regulation of autophagy →	+0.035	+0.497	.005	.009	2	12
LARGE_INTESTINE	Viral process →	+0.061	+0.632	<.001	.002	3	11
CNS	Cytosolic transport →	+0.061	+0.739	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,862 associations by consensus.

Intracellular receptor signaling pathway by UBC expression — SOFT_TISSUE

Explore this box plot interactively →