UBC

Across TCGA cell cohorts, UBC mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBC-associated genes across cancer lineages are KRT76, C6orf118, and COX6A2. Each is linked with UBC in more than 1 cancer types. Because this analysis shows association rather than direction, both UBC-to-partner and partner-to-UBC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT76 grouped by UBC-low versus UBC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBC→partner) and Y-score (partner→UBC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT76 →	+0.306	+4.947	<.001	.001	3	1
LARGE_INTESTINE	C6orf118 →	+0.108	+3.115	<.001	.004	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ARL13A →	+0.066	+3.369	.004	.007	3	1
LARGE_INTESTINE	MRGPRX3 →	+0.348	+2.878	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRT76 by UBC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →