UBBP4

Across TCGA patient cohorts, UBBP4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBBP4-associated genes across cancer lineages are ASNS, STAT3_pY705, and TFRC. Each is linked with UBBP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBBP4-to-partner and partner-to-UBBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UBBP4-low versus UBBP4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBBP4→partner) and Y-score (partner→UBBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.383	+2.459	.036	.018	3	3
UCEC	STAT3_pY705 →	-0.278	-1.502	<.001	.025	3	3
SKCM	TFRC →	+0.813	+2.584	.001	.011	3	3
UCEC	GAPDH →	+0.423	+2.222	.011	.009	3	2
UCEC	Notch1 →	+0.125	+1.290	.004	.034	3	2
UCEC	C-Raf →	+0.150	+1.999	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by UBBP4 expression — LUAD

Explore this box plot interactively →