UBAP2

Across TCGA cell cohorts, UBAP2 mutation is significantly associated with the mutation status of many other genes, with 5,842 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBAP2-associated genes across cancer lineages are ITPR1, ZNF71, and TNS2. Each is linked with UBAP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both UBAP2-to-partner and partner-to-UBAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITPR1 grouped by UBAP2-low versus UBAP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBAP2→partner) and Y-score (partner→UBAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITPR1 →	+2.399	+2.962	.002	.002	1	5
OVARY	ZNF71 →	+4.415	+4.977	.007	.007	1	5
UPPER_AERODIGESTIVE_TRACT	TNS2 →	+4.392	+4.954	.008	.008	1	5
BLOOD_Leukemia	PRRC2B →	+2.440	+3.364	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	SEMA6D →	+4.392	+4.954	.008	.008	1	4
OVARY	DGKZ →	+4.415	+4.977	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,842 associations by consensus.

ITPR1 by UBAP2 expression — BLOOD_Leukemia

Explore this box plot interactively →