UBAP1

Across TCGA pan-cancer cohorts, UBAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBAP1 data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBAP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where UBAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.962	0.736	.004	41	view →
PDAC	DFS	Tertile	II,III,IV	0.539	0.299	.014	21	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.473	.018	10	view →
CCRCC	OS	Median	All	0.905	0.763	.028	3	view →
LUAD	OS	Quartile	III,IV	1.000	0.763	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBAP1–HNSC (OS)

Open the HNSC breakdown →