UBAP1

Across TCGA patient cohorts, UBAP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBAP1-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with UBAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBAP1-to-partner and partner-to-UBAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by UBAP1-low versus UBAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBAP1→partner) and Y-score (partner→UBAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.211	+2.000	.012	.010	3	2
UCEC	14-3-3_beta →	-0.107	-2.095	.006	.017	3	1
UCEC	EGFR_pY1068 →	-0.224	-2.584	.022	.010	3	1
UCEC	ACC_pS79 →	+0.377	+3.321	.005	.009	3	1
UCEC	ACC1 →	+0.413	+2.335	.003	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.134	-2.115	.043	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PCNA by UBAP1 expression — UCEC

Explore this box plot interactively →