UBA6

Across TCGA pan-cancer cohorts, UBA6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UBA6 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UBA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBA6 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, HNSC, and LUAD are the cancer types where UBA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.870	1.000	.011	72	view →
HNSC	DFS	Tertile	IV	0.924	0.577	.006	36	view →
LUAD	OS	Median	All	0.620	0.887	<.001	16	view →
LSCC	OS	Quartile	II,III,IV	0.616	0.942	.009	15	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
UCEC	DFS	Tertile	All	0.902	1.000	.014	6	view →
CCRCC	OS	Median	All	0.750	1.000	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UBA6–COAD (DFS)

Open the COAD breakdown →