UBA6

Across TCGA patient cohorts, UBA6 mutation is significantly associated with the RNA expression of many other genes, with 5,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA6-associated genes across cancer lineages are PCCB, UBAC1, and SKA1. Each is linked with UBA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBA6-to-partner and partner-to-UBA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCCB grouped by UBA6-low versus UBA6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA6→partner) and Y-score (partner→UBA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCCB →	+0.414	+3.205	.005	.009	3	3
LUAD	UBAC1 →	+0.322	+3.366	.006	.004	3	3
LUAD	SKA1 →	+0.838	+2.257	.002	.006	3	3
UCEC	SAAL1 →	+0.525	+1.530	<.001	<.001	3	3
LUAD	TUBA1C →	+0.557	+2.234	.003	.006	3	3
LUAD	KPNA2 →	+0.840	+2.906	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,827 associations by consensus.

PCCB by UBA6 expression — LUAD

Explore this box plot interactively →