UBA6

Across TCGA patient cohorts, UBA6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA6-associated genes across cancer lineages are ATM, AR, and IGFBP2. Each is linked with UBA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both UBA6-to-partner and partner-to-UBA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UBA6-low versus UBA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA6→partner) and Y-score (partner→UBA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.503	-3.446	<.001	<.001	3	4
UCEC	AR →	-0.227	-0.951	.025	.037	3	3
LUAD	IGFBP2 →	-0.665	-3.321	.041	.009	3	2
UCEC	EGFR_pY1068 →	-0.228	-1.765	<.001	<.001	3	2
UCEC	FoxM1 →	+0.149	+0.951	.034	.037	3	2
UCEC	GATA6 →	-0.107	-1.577	.015	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

ATM by UBA6 expression — UCEC

Explore this box plot interactively →