UBA6

Across TCGA cell cohorts, UBA6 mutation is significantly associated with the RNA expression of many other genes, with 324 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBA6-associated genes across cancer lineages are EVX2, PROP1, and IFNE. Each is linked with UBA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA6-to-partner and partner-to-UBA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EVX2 grouped by UBA6-low versus UBA6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA6→partner) and Y-score (partner→UBA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EVX2 →	+0.033	+4.169	<.001	.002	3	2
LUNG_SCLC	PROP1 →	+0.178	+3.428	.004	.008	3	1
LUNG_SCLC	IFNE →	+0.569	+3.376	<.001	.009	3	1
OVARY	CCDC60 →	+0.043	+3.643	.001	.002	3	1
OVARY	KLF18 →	+0.008	+3.095	.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.524	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 324 associations by consensus.

EVX2 by UBA6 expression — OVARY

Explore this box plot interactively →