UBA5

Across TCGA pan-cancer cohorts, UBA5 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UBA5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where UBA5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UBA5 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where UBA5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBA5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.519	<.001	12	view →
LSCC	Female	II,III,IV	+0.329	<.001	8	view →
PDAC	Female	All	−0.877	<.001	7	view →
COAD	Male	All	−0.171	<.001	6	view →
LUAD	Male	All	+0.150	<.001	5	view →
HNSC	Male	IV	+0.227	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UBA5–CCRCC

Open the CCRCC breakdown →