UBA3

Across TCGA pan-cancer cohorts, UBA3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UBA3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UBA3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBA3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where UBA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.664	0.996	.015	13	view →
HNSC	OS	Tertile	II,III,IV	0.924	1.000	.007	13	view →
LUAD	OS	Quartile	III,IV	0.898	0.296	.035	6	view →
GBM	DFS	Tertile	All	0.193	0.469	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UBA3–LSCC (OS)

Open the LSCC breakdown →