UBA3

Across TCGA patient cohorts, UBA3 mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA3-associated genes across cancer lineages are RNA5SP86, RPS12P15, and RNU6-1023P. Each is linked with UBA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA3-to-partner and partner-to-UBA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by UBA3-low versus UBA3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA3→partner) and Y-score (partner→UBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP86 →	+1.964	+7.142	<.001	<.001	3	2
COAD	RPS12P15 →	+0.275	+5.693	<.001	.003	3	2
COAD	RNU6-1023P →	+0.692	+7.734	<.001	<.001	3	2
COAD	RNA5SP134 →	+1.658	+5.145	.001	.007	3	2
COAD	PSMB7P1 →	+0.183	+5.790	<.001	.003	3	2
UCEC	RNU1-17P →	+0.236	+2.087	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

RNA5SP86 by UBA3 expression — COAD

Explore this box plot interactively →