UBA2

Across TCGA pan-cancer cohorts, UBA2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBA2 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBA2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UBA2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where UBA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.783	0.913	.038	20	view →
UCEC	OS	Median	II,III,IV	0.653	1.000	.020	18	view →
CCRCC	DFS	Median	All	0.867	0.963	.007	15	view →
GBM	OS	Median	All	0.505	0.289	.024	6	view →
LSCC	DFS	Quartile	II,III,IV	0.923	0.474	.026	2	view →
LUAD	DFS	Tertile	All	0.919	0.657	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBA2–HNSC (OS)

Open the HNSC breakdown →