UBA2

Across TCGA cell cohorts, UBA2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBA2-associated genes across cancer lineages are USP14, ARL1, and SFTPA1. Each is linked with UBA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA2-to-partner and partner-to-UBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by UBA2-low versus UBA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA2→partner) and Y-score (partner→UBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.752	+3.067	.002	.009	3	1
LARGE_INTESTINE	ARL1 →	+0.565	+3.304	.002	.005	3	1
LARGE_INTESTINE	SFTPA1 →	+0.123	+2.782	<.001	.007	3	1
LARGE_INTESTINE	CES3 →	+1.693	+3.082	.001	.007	3	1
LARGE_INTESTINE	FBXO42 →	+0.812	+3.064	<.001	.009	3	1
LARGE_INTESTINE	BAAT →	+0.483	+3.465	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

USP14 by UBA2 expression — LARGE_INTESTINE

Explore this box plot interactively →