UBA1

Across TCGA pan-cancer cohorts, UBA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBA1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UBA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UBA1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where UBA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	9	view →
COAD	DFS	Median	IV	0.432	0.944	.012	6	view →
HNSC	OS	Median	All	0.936	0.993	.015	6	view →
GBM	DFS	Median	All	0.486	0.258	.016	6	view →
PDAC	DFS	Tertile	IV	0.203	0.752	.024	3	view →
UCEC	OS	Median	All	0.912	0.985	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBA1–CCRCC (DFS)

Open the CCRCC breakdown →