UBA1

Across TCGA patient cohorts, UBA1 mutation is significantly associated with the RNA expression of many other genes, with 4,308 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA1-associated genes across cancer lineages are KCTD9, DDX55, and RFC5. Each is linked with UBA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBA1-to-partner and partner-to-UBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by UBA1-low versus UBA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA1→partner) and Y-score (partner→UBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.678	+2.368	<.001	<.001	3	3
UCEC	DDX55 →	+0.315	+1.624	<.001	.001	3	3
UCEC	RFC5 →	+0.435	+2.148	<.001	<.001	3	3
UCEC	KIF20A →	+0.473	+1.332	.002	.001	3	3
UCEC	ARL1 →	+0.362	+1.855	<.001	<.001	3	3
UCEC	RAB9A →	+0.453	+1.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,308 associations by consensus.

KCTD9 by UBA1 expression — UCEC

Explore this box plot interactively →