UBA1

Across TCGA patient cohorts, UBA1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBA1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and c-Kit. Each is linked with UBA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA1-to-partner and partner-to-UBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBA1-low versus UBA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA1→partner) and Y-score (partner→UBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.131	+1.106	.027	.020	3	2
UCEC	Caspase-7-cleavedD198 →	+0.649	+2.157	<.001	<.001	3	2
UCEC	c-Kit →	-0.136	-1.273	.037	.007	3	2
UCEC	Cyclin-B1 →	+0.537	+2.502	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.099	-2.365	<.001	<.001	3	1
UCEC	eIF4G →	+0.239	+2.115	.006	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by UBA1 expression — UCEC

Explore this box plot interactively →