UBA1

Across TCGA cell cohorts, UBA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,258 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UBA1-associated GO terms across cancer lineages are Growth hormone secretion, Negative regulation of heterochromatin organization, and Negative regulation of heterochromatin formation. Each is linked with UBA1 in more than 18 cancer types. Because this analysis shows association rather than direction, both UBA1-to-partner and partner-to-UBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone secretion grouped by UBA1-low versus UBA1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA1→partner) and Y-score (partner→UBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Growth hormone secretion →	+0.141	+0.564	.004	.005	3	19
CNS	Negative regulation of heterochromatin organization →	+0.108	+0.636	<.001	<.001	3	15
CNS	Negative regulation of heterochromatin formation →	+0.108	+0.636	<.001	<.001	3	15
LARGE_INTESTINE	Nucleosome disassembly →	+0.143	+0.711	<.001	<.001	3	14
PANCREAS	Positive regulation of mitotic cytokinesis →	+0.121	+0.621	.001	.009	2	14
BONE	Mitotic spindle midzone assembly →	+0.317	+1.064	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,258 associations by consensus.

Growth hormone secretion by UBA1 expression — BLOOD_Myeloma

Explore this box plot interactively →