UBA1

Across TCGA cell cohorts, UBA1 mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UBA1-associated genes across cancer lineages are LCE1C, ANKRD54, and CBY1. Each is linked with UBA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBA1-to-partner and partner-to-UBA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1C grouped by UBA1-low versus UBA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBA1→partner) and Y-score (partner→UBA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LCE1C →	+0.062	+5.196	<.001	.005	3	1
LARGE_INTESTINE	ANKRD54 →	+0.552	+3.067	.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.811	+3.482	<.001	<.001	3	1
LARGE_INTESTINE	POLR3H →	+0.852	+3.169	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.512	+2.667	<.001	.007	3	1
LARGE_INTESTINE	TRIM37 →	+0.602	+3.364	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

LCE1C by UBA1 expression — OVARY

Explore this box plot interactively →